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Longevity Research

Zest conducts scientific research, in partnership with the University of Cambridge in the UK. These studies investigate declining cognitive performance with age. We are also committed to sharing leading peer reviewed research into human longevity from doctors and longevity scientists across the globe, as part of our commitment to make longevity science accessible to all.

Evaluating Novel Health Assessments and Neurocognitive
Changes for Extended Lifespan

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Zest ENHANCE studies

ENHANCE
1
Pilot
In partnership with Cambridge, Zest is delivering the Precision Memory Test through its app to a pilot group of 300 participants. This study is exploring how memory performance changes with age and how it relates to broader markers of brain aging.
In partnership with researchers at:
ENHANCE
2
Validation
To enable wider adoption, Zest is scaling the test to 3,000 participants via its mobile app. This phase aims to validate early findings and establish Cambridge’s Precision Memory Test as a powerful, accessible tool for tracking brain aging in the general population.
In partnership with researchers at:
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Summary:
This study found that a 5-minute cold-water immersion at 20 °C significantly improved mood in healthy adults new to cold exposure. Participants felt more alert, active, and inspired, with reduced distress and nervousness. Brain scans (fMRI) revealed that increases in positive mood were linked to stronger connectivity between networks involved in attention, emotion, and self-regulation—specifically the default mode, frontoparietal, salience, and visual networks. Changes in negative emotions showed weaker brain associations. These findings suggest cold-water immersion boosts mood by enhancing brain network integration, supporting its potential as a mental health intervention.
December 19, 2022
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Summary:
This study analyzes data from 101 countries to explore how shifts from animal-based to plant-based protein impact age-specific mortality. It finds that higher animal protein and fat intake support early-life survival, while plant-based protein and lower fat improve later-life outcomes. The research suggests that optimizing national diets for both health and sustainability requires age-specific adjustments in protein and fat distribution.
April 11, 2025
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Summary:
This study using UK Biobank data shows that sustained dietary changes from unhealthy eating to the Eatwell Guide or longevity-focused diets can increase life expectancy by up to 10.8 years. The biggest gains come from eating more whole grains, nuts, and fruits while reducing sugary drinks and processed meats. These findings highlight the powerful role of long-term dietary habits in preventing disease and shaping public health policy.
November 20, 2023
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Summary:
This study found that in men aged 60 to 79, higher levels of DHEAS are independently linked to greater muscle strength and mass, even after adjusting for testosterone and other confounders. The findings support the idea that declining DHEAS may contribute to age-related muscle loss and suggest the need for further research into its role in sarcopenia.
May 5, 2019
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Summary:
those with lower total testosterone levels had a significantly higher risk of developing dementia and Alzheimer’s disease. Men in the lowest testosterone quintile had a 43% higher risk of dementia and an 80% higher risk of Alzheimer’s compared to those with the highest levels. These findings suggest that hormonal balance may play a key role in protecting brain health during aging.
January 3, 2022
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Summary:
This study found that aging significantly impairs the ability to remember the order of events—an essential aspect of episodic memory. Older adults performed well on familiar, predictable sequences but struggled with novel sequences, especially when detailed sequence knowledge was required. This decline in sequence memory became more pronounced with age and was not captured by traditional memory tests. The findings highlight that sequence memory is a sensitive marker of age-related cognitive decline and could serve as an early indicator of memory impairment.
January 3, 2022
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Frequently Asked Questions

  1. Order your functional age test via our website
  2. Receive your at-home finger prick blood test kit, collect your dried blood sample and send it off in the prepaid mailer.
  3. Download our app and receive your blood test results directly to your phone, no need for any follow-up results appointments
  4. Repeat steps 6 & 7 until you find the perfect and most optimized longevity protocol for you, and then use the app to stay accountable.
  5. Download our app and select a membership that works for you. 
  6. Start following our science-backed longevity protocol.
  7. Watch your functional age score come down, continue adding the new recommendations to your daily protocol, and iterate towards a lower biological age over time.
  • Your chosen longevity supplement stack, delivered monthly.
  • Zest longevity blood panel delivered every 3 months. This is an at-home finger-prick blood test consisting of the 9 blood biomarkers most closely linked to healthspan and lifespan.
  • Access to the Zest app.
  • Zest biological age calculation (coming soon).

The supplement subscription only includes supplements and app access, no blood tests. Without the blood biomarkers, we are unable to calculate biological age.

Mainstream supplements are typically designed to augment ingredients which you could regularly find in your diet to help you meet your daily recommendations. Longevity molecules are different because:

1) you don’t find any of these ingredients in your regular diet and
2) there are no established daily recommendations of these ingredients.

These ingredients have come out of recent cutting-edge research on how to biologically slow the aging process. There aren’t any government guidelines recommending certain levels of these ingredients to promote health, since they are so new and they target the aging process as a whole rather than focusing on a specific disease. Our ingredients cannot be found in most supermarkets or drug stores.

  • At 7.2 g grams per dose, we have the highest amount of pure active ingredients of any other longevity company on the market, so you’re actually getting therapeutic doses that make a difference.
  • We have the purest and highest quality ingredients, and provide purity reports and 3rd party Lab Testing as well as sourcing information for all ingredients.
  • We don’t mess around with vitamin gummies, green juice blends, or other influencer fads which aren’t backed by science. We only supply the real deal, high quality and therapeutic doses backed by 100+ clinical trials.
  • We separate our supplement packs into hydrophobic and hydrophilic to optimize absorption and reduce gastrointestinal upset. This means the ingredients are actually getting into your cells, unlike for many multivitamin companies which just cause you to make expensive pee.
  • We have expertly curated our supplement stacks to target all 12 root causes of aging, making you biologically younger on the inside.

Zest’s functional age calculation is the most accurate and holistic biological age score on the market, and the only one which takes into account your cognitive function as well as your physical health. We use a combination of blood biomarkers, digital biomarkers and functional biomarkers (including memory tests) which we run through our machine learning algorithm to give you the most accurate and research-backed biological age measurement yet. Our blood test includes markers for your cholesterol levels, hormone levels, liver enzymes, and other tests grounded in 100+ years of research (the OG science, not just the latest fads). We then add this to our digital biomarkers such as resting heart rate, sleep, mood, VO2 max score, and other metrics which give real insight into your day to day functionality. Finally we include grip strength and some cognitive tests as part of our “functional biomarkers” and together this makes up the data that goes into our functional age algorithm to give you a result for your biological age.

At Zest, we want to make longevity easy. We have a team of medical doctors and longevity scientists constantly examining the latest literature to determine which ingredients should go into the ultimate life-extending supplement stack. We continuously update these packs as new research emerges to ensure the ingredients you’re taking are at the forefront of medical and scientific research. No need to spend hours doing your own research, we are the experts and we have you covered! Just subscribe to the membership and Zest takes care of the rest.

The Zest app is downloadable from all countries. Currently our blood tests and supplement packs are currently only available in the USA and Canada.

Still have a questions?