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Longevity Research

At Zest, we’re redefining the detection of cognitive decline.
In partnership with the University of Cambridge, we have launched PREMAZ: a digital cognitive assessment  measureing Memory Precision, one of the earliest and most sensitive markers of brain aging. It picks up what standard tests miss, giving our users a powerful head start in protecting long-term brain health.

We also collate and share the latest longevity breakthroughs from world-leading scientists. We are proud to showcase the research that underpins the Zest ecosystem.

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Precision Memory Assesement by Zest
PREMAZ

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Zest PREMAZ studies

PREMAZ
1
Pilot
In partnership with Cambridge, Zest is delivering the Precision Memory Test through its app to a pilot group of 100 participants. This study is exploring usability and ease of access to our new app based DCA to ensure the test is accessible and repeatable in diverse populations .
In partnership with researchers at:
PREMAZ
2
Validation
To enable wider adoption, Zest is scaling the test to 3,000 participants via its mobile app. This phase aims to validate the PREMAZ test on a mobile device for clinical adoption. This data will be used in the 7th peer reviewed publication on the PREMAZ test, confirming it's validity and accuracy for detecting cognitive decline earlier than current gold standard cognitive tests.
In partnership with researchers at:
All
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Short-Term Head-Out Whole-Body Cold-Water Immersion Facilitates Positive Affect and Increases Interaction between Large-Scale Brain Networks

Summary:
This study found that a 5-minute cold-water immersion at 20 °C significantly improved mood in healthy adults new to cold exposure. Participants felt more alert, active, and inspired, with reduced distress and nervousness. Brain scans (fMRI) revealed that increases in positive mood were linked to stronger connectivity between networks involved in attention, emotion, and self-regulation—specifically the default mode, frontoparietal, salience, and visual networks. Changes in negative emotions showed weaker brain associations. These findings suggest cold-water immersion boosts mood by enhancing brain network integration, supporting its potential as a mental health intervention.
Hot & Cold Exposure
December 19, 2022
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Associations between national plant-based vs animal-based protein supplies and age-specific mortality in human populations

Summary:
This study analyzes data from 101 countries to explore how shifts from animal-based to plant-based protein impact age-specific mortality. It finds that higher animal protein and fat intake support early-life survival, while plant-based protein and lower fat improve later-life outcomes. The research suggests that optimizing national diets for both health and sustainability requires age-specific adjustments in protein and fat distribution.
Diet
April 11, 2025
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Life expectancy can increase by up to 10 years following sustained shifts towards healthier diets in the United Kingdom

Summary:
This study using UK Biobank data shows that sustained dietary changes from unhealthy eating to the Eatwell Guide or longevity-focused diets can increase life expectancy by up to 10.8 years. The biggest gains come from eating more whole grains, nuts, and fruits while reducing sugary drinks and processed meats. These findings highlight the powerful role of long-term dietary habits in preventing disease and shaping public health policy.
Diet
November 20, 2023
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Effect of DHEAS on skeletal muscle over the life span

Summary:
This study found that in men aged 60 to 79, higher levels of DHEAS are independently linked to greater muscle strength and mass, even after adjusting for testosterone and other confounders. The findings support the idea that declining DHEAS may contribute to age-related muscle loss and suggest the need for further research into its role in sarcopenia.
Blood Biomarkers
May 5, 2019
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Lower serum testosterone concentrations are associated with a higher incidence of dementia in men.

Summary:
those with lower total testosterone levels had a significantly higher risk of developing dementia and Alzheimer’s disease. Men in the lowest testosterone quintile had a 43% higher risk of dementia and an 80% higher risk of Alzheimer’s compared to those with the highest levels. These findings suggest that hormonal balance may play a key role in protecting brain health during aging.
Blood Biomarkers
January 3, 2022
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Memory for sequences of events impaired in typical aging

Summary:
This study found that aging significantly impairs the ability to remember the order of events—an essential aspect of episodic memory. Older adults performed well on familiar, predictable sequences but struggled with novel sequences, especially when detailed sequence knowledge was required. This decline in sequence memory became more pronounced with age and was not captured by traditional memory tests. The findings highlight that sequence memory is a sensitive marker of age-related cognitive decline and could serve as an early indicator of memory impairment.
Functional Longevity Tests
January 3, 2022
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Frequently Asked Questions

Your kit includes everything you need to collect a small blood sample at home, safely and easily. Inside you’ll find a lancet, collection cards, alcohol swabs, bandages, and a pre-paid return envelope. No lab visits, no hassle.

Once your blood sample is returned, we analyze key biomarkers linked to aging and combine them with data from your wearable devices and in-app functional performance tests. Our machine learning algorithm calculates your Functional Age a snapshot of how old your body really is compared to your chronological age. We also provide a peronsalized protocol for you to improve your scores.

Zest blood tests anlayze clinically relevant blood biomarkers including:
‍
‍Inflammation: CRP
‍Metabolic health: HbA1c, fasting glucose, triglycerides
‍Cardiovascular risk: LDL, HDL, ApoB
‍Liver & protein status: Albumin
‍Hormones (for men & women): Testosterone, Oestradiol, SHBG, DHEAS

We recommend retesting every 3 to track your progress, assess what’s working, and update your personalized protocol. Functional age is dynamic, and improvements are often visible within just a few months of following your plan.

All of your results, scores, and recommendations are delivered in the Zest app. You’ll get a breakdown of your Functional Age, biomarker analysis, and a tailored plan covering supplements, training, recovery, nutrition, and sleep.

Zest offers targeted longevity supplements designed to support the areas that impact your biological age the most, such as cellular energy, inflammation, brain health, and hormone balance. Your personalized protocol will recommend the right supplements based on your test results.

Still have a questions?

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