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Longevity Research

At Zest, we’re redefining the detection of cognitive decline.
In partnership with the University of Cambridge, we have launched PREMAZ: a digital cognitive assessment  measureing Memory Precision, one of the earliest and most sensitive markers of brain aging. It picks up what standard tests miss, giving our users a powerful head start in protecting long-term brain health.

We also collate and share the latest longevity breakthroughs from world-leading scientists. We are proud to showcase the research that underpins the Zest ecosystem.

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Precision Memory Assesement by Zest
PREMAZ

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Zest PREMAZ studies

PREMAZ
1
Pilot
In partnership with Cambridge, Zest is delivering the Precision Memory Test through its app to a pilot group of 100 participants. This study is exploring usability and ease of access to our new app based DCA to ensure the test is accessible and repeatable in diverse populations .
In partnership with researchers at:
PREMAZ
2
Validation
To enable wider adoption, Zest is scaling the test to 3,000 participants via its mobile app. This phase aims to validate the PREMAZ test on a mobile device for clinical adoption. This data will be used in the 7th peer reviewed publication on the PREMAZ test, confirming it's validity and accuracy for detecting cognitive decline earlier than current gold standard cognitive tests.
In partnership with researchers at:
All
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Eight brain structures mediate the age-related alterations of the working memory: forward and backward digit span tasks

Summary:
This study found that aging is linked to declines in working memory, reduced gray matter volume in key brain regions, and lower activity in major brain networks. Specifically, the medial orbitofrontal cortex, thalamus, and other regions were shown to mediate age-related differences in memory tasks. These findings highlight structural and functional brain changes that underlie memory decline with age and suggest potential early markers for identifying individuals at risk of cognitive decline.
Functional Longevity Tests
September 3, 2024
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Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study

Summary:
This large-scale UK Biobank study found that consistent sleep-wake timing (sleep regularity) is a stronger predictor of mortality than sleep duration. People with the most regular sleep patterns had up to 48% lower risk of all-cause mortality, 39% lower cancer mortality, and 57% lower cardiometabolic mortality, even after adjusting for health and lifestyle factors. Unlike duration alone, regularity showed a clear and independent impact on longevity, highlighting it as a key target for improving health and survival.
Biological Aging
September 21, 2023
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Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan

Summary:
This study found that reduced memory precision is an early sign of cognitive aging, detectable from midlife. Using tasks that measured how accurately people remembered object details and locations, researchers showed that deficits in perceptual and memory fidelity impact both short-term and long-term memory. Standard memory tests were less sensitive to these subtle declines. Precision-based tasks may offer a more effective way to detect early cognitive decline than traditional testing.
Functional Longevity Tests
January 1, 2024
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Exploring grip strength as a predictor of depression in middle-aged and older adults

Summary:
lower grip strength is linked to higher odds of depression in middle-aged and older adults across Europe. While grip strength showed only weak ability to accurately identify depression, specific cut-off values (e.g. 43.5 kg for men and 29.5 kg for women aged 50–64) were associated with significantly lower depression risk both at baseline and four years later. Grip strength may be useful as a general screening tool for vulnerability to depression, but it should not be used alone to diagnose it.
Exercise
May 5, 2021
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Associations of grip strength with cardiovascular, respiratory, and cancer outcomes

Summary:
lower grip strength is strongly associated with increased risk of all-cause and disease-specific mortality, including cardiovascular, respiratory, and several types of cancer. Every 5 kg drop in grip strength significantly raised mortality risk, especially in younger individuals. Muscle weakness was linked to worse outcomes across nearly all conditions. Adding grip strength to traditional risk models improved their ability to predict mortality and disease, highlighting its potential as a simple, powerful tool for early risk screening in clinical practice.
Exercise
May 18, 2018
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Comparison of grip strength measurements for predicting all-cause mortality among adults

Summary:
lower handgrip strength is strongly linked to a higher risk of all-cause mortality across all age and sex groups. The most effective predictors were simple measures like average (HGS) and maximum grip strength (MGS), followed by grip strength adjusted for height squared (HGS/HT²). Individuals in the lowest 20% for grip strength had more than double the risk of death. Maintaining strong grip strength may play a key role in lowering mortality risk.
Functional Longevity Tests
November 5, 2024
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Frequently Asked Questions

Your kit includes everything you need to collect a small blood sample at home, safely and easily. Inside you’ll find a lancet, collection cards, alcohol swabs, bandages, and a pre-paid return envelope. No lab visits, no hassle.

Once your blood sample is returned, we analyze key biomarkers linked to aging and combine them with data from your wearable devices and in-app functional performance tests. Our machine learning algorithm calculates your Functional Age a snapshot of how old your body really is compared to your chronological age. We also provide a peronsalized protocol for you to improve your scores.

Zest blood tests anlayze clinically relevant blood biomarkers including:
‍
‍Inflammation: CRP
‍Metabolic health: HbA1c, fasting glucose, triglycerides
‍Cardiovascular risk: LDL, HDL, ApoB
‍Liver & protein status: Albumin
‍Hormones (for men & women): Testosterone, Oestradiol, SHBG, DHEAS

We recommend retesting every 3 to track your progress, assess what’s working, and update your personalized protocol. Functional age is dynamic, and improvements are often visible within just a few months of following your plan.

All of your results, scores, and recommendations are delivered in the Zest app. You’ll get a breakdown of your Functional Age, biomarker analysis, and a tailored plan covering supplements, training, recovery, nutrition, and sleep.

Zest offers targeted longevity supplements designed to support the areas that impact your biological age the most, such as cellular energy, inflammation, brain health, and hormone balance. Your personalized protocol will recommend the right supplements based on your test results.

Still have a questions?

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