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Longevity Research

At Zest, we’re redefining the detection of cognitive decline.
In partnership with the University of Cambridge, we have launched PREMAZ: a digital cognitive assessment  measureing Memory Precision, one of the earliest and most sensitive markers of brain aging. It picks up what standard tests miss, giving our users a powerful head start in protecting long-term brain health.

We also collate and share the latest longevity breakthroughs from world-leading scientists. We are proud to showcase the research that underpins the Zest ecosystem.

Precision Memory Assesement by Zest
PREMAZ

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Zest PREMAZ studies

PREMAZ
1
Pilot
In partnership with Cambridge, Zest is delivering the Precision Memory Test through its app to a pilot group of 100 participants. This study is exploring usability and ease of access to our new app based DCA to ensure the test is accessible and repeatable in diverse populations .
In partnership with researchers at:
PREMAZ
2
Validation
To enable wider adoption, Zest is scaling the test to 3,000 participants via its mobile app. This phase aims to validate the PREMAZ test on a mobile device for clinical adoption. This data will be used in the 7th peer reviewed publication on the PREMAZ test, confirming it's validity and accuracy for detecting cognitive decline earlier than current gold standard cognitive tests.
In partnership with researchers at:
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Summary:
This meta-analysis found that low levels of DHEAS are linked to a higher risk of all-cause and cardiovascular mortality in older adults. The risk was particularly evident in men. These findings suggest DHEAS may be a useful biomarker for mortality risk in the elderly.
September 3, 2020
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Summary:
Higher serum estradiol levels were linked to better cognitive performance—specifically processing speed, attention, and working memory—in older American women. The strongest association was seen in those with the highest estradiol levels (T3 group), based on improved DSST scores. No significant links were found with other cognitive tests.
February 21, 2024
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Summary:
In postmenopausal women over 65, higher levels of natural (endogenous) estradiol are associated with a significantly increased risk of ischemic arterial disease, including coronary heart disease and possibly stroke. This link remains even after adjusting for common cardiovascular risk factors like BMI, diabetes, and smoking. In contrast, testosterone levels showed no association with cardiovascular risk. These findings suggest that estradiol may be a valuable early biomarker for identifying older women at greater risk of heart disease.
June 8, 2012
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Summary:
This large meta-analysis of over 255,000 participant-years found that low testosterone, high luteinizing hormone (LH), and very low estradiol levels in men are linked to higher all-cause mortality. Low testosterone (<5.3 nmol/L) also predicted increased cardiovascular death. These findings suggest that balanced sex hormone levels may support longevity and reduce cardiovascular risk in aging men.
May 14, 2024
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Summary:
Researchers found that low levels of NT-proBNP were strongly associated with survival to supercentenarian age. Other markers linked to all-cause mortality included interleukin-6, cystatin C, and cholinesterase, while low albumin consistently predicted higher mortality across all age groups. These insights suggest that specific cardiovascular and inflammatory biomarkers may play a crucial role in resisting age-related diseases and achieving extreme longevity.
July 3, 2020
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Summary:
This population-based study found that higher SHBG levels were associated with increased all-cause mortality in both men and women. In men, lower total and free testosterone were linked to higher mortality risk, while in women, higher DHT levels were also associated with increased risk. These findings suggest that imbalances in sex hormone levels—especially SHBG and testosterone—may impact longevity differently in men and women, highlighting the importance of sex-specific hormone monitoring in aging and health risk assessment.
April 3, 2023
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Frequently Asked Questions

Your kit includes everything you need to collect a small blood sample at home, safely and easily. Inside you’ll find a lancet, collection cards, alcohol swabs, bandages, and a pre-paid return envelope. No lab visits, no hassle.

Once your blood sample is returned, we analyze key biomarkers linked to aging and combine them with data from your wearable devices and in-app functional performance tests. Our machine learning algorithm calculates your Functional Age a snapshot of how old your body really is compared to your chronological age. We also provide a peronsalized protocol for you to improve your scores.

Zest blood tests anlayze clinically relevant blood biomarkers including:

Inflammation: CRP
Metabolic health: HbA1c, fasting glucose, triglycerides
Cardiovascular risk: LDL, HDL, ApoB
Liver & protein status: Albumin
Hormones (for men & women): Testosterone, Oestradiol, SHBG, DHEAS

We recommend retesting every 3 to track your progress, assess what’s working, and update your personalized protocol. Functional age is dynamic, and improvements are often visible within just a few months of following your plan.

All of your results, scores, and recommendations are delivered in the Zest app. You’ll get a breakdown of your Functional Age, biomarker analysis, and a tailored plan covering supplements, training, recovery, nutrition, and sleep.

Zest offers targeted longevity supplements designed to support the areas that impact your biological age the most, such as cellular energy, inflammation, brain health, and hormone balance. Your personalized protocol will recommend the right supplements based on your test results.

Still have a questions?